Micro-bio 3D printed stent regenerates damaged peripheral nerves
Scientists at the University of Saskatchewan in Canada have reportedly developed tiny 3D printed stents that can guide the regeneration of nerve cells and possibly restore the tactile and motor control of patients with impaired peripheral nervous system. This tiny bioprinted stent is less than one centimeter in length on each side.
The peripheral nerves are the connections between our brains and spinal cords and other parts of our body. They are fragile and easily damaged. It can be devastated by diseases such as toxins, bad diets, trauma or diabetes, which affect about 422 million people worldwide. The nerve is surrounded by tissue and acts as an insulator. Damage to the peripheral nervous system affects our tactile and motor control, and severe peripheral nerve damage can lead to a complete loss of sensation in the area.
The current standard for treating large gaps in the nervous system due to injury is autologous autografting, donor nerve transplantation from another part of the body, and nerve gaps for repairing and closing peripheral nerve injuries. However, this process is not perfect, the donor site for nerve repair is limited, and even successful grafts usually only recover part of the original function of the nerve. The CLS phase contrast imaging computed tomography provides accurate and highly detailed 3D reconstruction of the stent to be produced.
Liqun Ning, a postdoctoral researcher in the Tissue Engineering Research Group led by Daniel Chen of the University of Saskatchewan, has been studying for years whether it can be combined with 3D printing and biotechnology to solve this problem and help nerve cell regeneration. Ning's work involves the use of Schwann cells to support cells in the nervous system, which can force nerve cells to grow normally on a 3D printed hydrogel scaffold to promote and guide the regeneration of damaged nerves. Liqun Ning prepared a solution to keep the sample holders fused.
At this point, it is desirable to address some of the problems in the stent before this method is seen for conventional medical use. He wants to try a few different techniques to better guide the development of the nervous system. An in vivo test will then be performed on the living animal to ensure that everything works as expected in the organism and is clinically tested.
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