Researchers of Chinese Academy of Sciences successfully constructed a new type of ultra-short carbon nanotube nanopore sensor
According to news from the National Natural Science Foundation of China, Wu Haichen's research group of the Institute of High Energy, Chinese Academy of Sciences, with the support of the National Natural Science Foundation of China, built a new type of ultra-short carbon nanotube nanopore sensor.
Nanopore single molecule detection technology is a brand-new technology developed in the past two decades. Its working principle is to apply an external electric field at both ends of the nanopore, by monitoring the weak current signal changes when the electrolyte flows through the nanopore (including Change the frequency, amplitude and fingerprint signal) to determine the concentration, charging status and structural characteristics of ions or molecules passing through the nanopore.
The technology is currently mainly used in DNA sequencing research. In single-molecule detection, single-point application research is also booming. At present, nanopores are mainly divided into protein nanopores and pores in the fields of inorganic solid-state nanoparticle chemical reactions and protein folding. Because of the advantages and disadvantages of these two types of nanopores, scientists have been working to construct different materials and properties. New nanopore sensor.
This time, Wu Haichen's research group of the Institute of High Energy, Chinese Academy of Sciences inserted a ultra-short single-walled carbon nanotube with a diameter of 1 to 2 nm and a length of 5 to 10 nm into a phospholipid bilayer membrane to construct a new type of nanopore based on ultra-short carbon nanotube The sensor has some unique physical properties of carbon nanotubes, such as a subatomic smooth inner surface, a large π conjugated system, and a super-hydrophobic internal environment. At the same time, the researchers also used this nanopore sensor for molecular experiments and achieved success.
This research further promotes the development of nanopore single molecule detection technology, and provides a brand new experimental model for the transport of ions and molecules in the lumen of carbon nanotubes.
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